Open Chemistry Journal

2014, 1 : 33-38
Published online 2014 December 31. DOI: 10.2174/1874842201401010033
Publisher ID: CHEM-1-33

RESEARCH ARTICLE
 Synthesis and Evaluation of New 2-Iminothiazolidin-4-one and Thiazolidin-2,4-dione Derivatives as Antimicrobial and Anti-inflammatory Agents

Waleed A. Bayoumi1, * , Shaymaa H. Abdel-Rhman2 and Mohamed E. Shaker3
1Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura 35516, Egypt;
2Department of Microbiology, Faculty of Pharmacy, University of Mansoura, Mansoura 35516, Egypt;
3Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Mansoura, Mansoura 35516, Egypt

* Address correspondence to this author at the Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura 35516, Egypt; Tel: +20 111 5633 722; Fax: +20 5022 4749; E-mail: waleedbayoumi@mans.edu.eg

ABSTRACT

A new series of 2-iminothiazolidin-4-ones and thiazolidin-2,4-diones were designed and synthesized. The target compounds were evaluated for antimicrobial and anti-inflammatory activities, aiming to find a candidate carrying dual activities. The antibacterial activity was determined by cup-diffusion technique and NCCLS broth dilution method. The MICs were determined using 96-well microtitre plates, while the anti-inflammatory activity was determined using carrageenan- induced rat paw edema model. The results revealed that target compounds showed no antifungal activity towards tested Fungi, whereas the antibacterial activity was mainly on Gram-positive bacteria. The anti-inflammatory activity was observed in compounds belonging to the thiazolidin-2,4-dione series. The structures of the newly synthesized compounds were confirmed by physical and spectral data.

Keywords::

2-iminothiazolidin-4-ones, anti-inflammatory, antimicrobial, synthesis, thiazolidin-2,4-diones.