Open Chemistry Journal

2015, 2 : 1-6
Published online 2015 February 27. DOI: 10.2174/1874842201502010001
Publisher ID: CHEM-2-1

RESEARCH ARTICLE
 Synthesis & Antifungal Screening of Novel Azetidin-2-ones

Apoorva Gupta, * and Anand K. Halve

*Address correspondence to this author at the School of Studies in Chemistry, Jiwaji University Gwalior-474011, India; Tel: 8305962885; E-mail: apoorva.phd12@gmail.com

ABSTRACT

A new series of 4-[3-chloro-2-(4-hydroxy-3-methoxybenzyllidene)-4-oxoazetidin-1-yl]amino-N-(substituted)benzenesulfonamide, 4-{3-chloro-2-[5-methoxy-2-nitro-4-(prop-2-en-1-yloxy)benz yllidene]-4-oxoazetidin-1-yl}]amino}-N-(substituted)benzenesulfonamide and 4-{3-chloro-2-[4-hydroxy-3-methoxy-5-(prop-2-en-1-yl)benzylidene]-4-oxoazetidin-1-yl}amino}-N-(substituted) benzenesulfonamide were synthesized using appropriate synthetic route. The chemical structures of all the synthesized compounds were deduced on the basis of elemental analysis and spectroscopic data. The antifungal activity of the synthesized compounds was screened against several fungus. The synthesized compounds show potent antifungal activity against Aspergillus niger & Aspergillus flavus and significant structure-activity relationship (SAR) trends.

Keywords:

, Azetidin-2-ones, SAR.