Open Chemistry Journal

3 : 17-24
Published online 2016 May 09. DOI: 10.2174/1874842201603010017
Publisher ID: CHEM-3-17

RESEARCH ARTICLE
Synthesis and Antifungal Evaluation of 5- Pyrazolones

Poonam Gupta, * and Jitendra K. Gupta
School of Studies in Chemistry, Jiwaji University Gwalior, India.

* Address correspondence to this author at the Research Scholar Jiwaji University, Gwalior, India; Tel: 9039926286; E-mail: poonamgupta_001@yahoo.com

ABSTRACT

A series of 4-chloro-3-methyl-N-(substituted phenyl)-5-oxo-4,5-dihydro-1H-pyrazole-1- carbothioamide were synthesized using earmark reaction of thiosemicarbazides and ethyl-2-chloroacetoacetate in DMF. All structures of the synthesized compounds were distinguished on the basis of IR, 1H-NMR, 13C-NMR and also elemental analysis. Synthesized Compounds were examined their potent antifungal activity using disc diffusion technique against three fungal pathogens viz Aspergillus niger, Candida albicans and Curvularia. Fluconazole were used as standard drug respectively. All compounds exhibited good to moderate activity.

Keywords:

Antifungal activity, disc diffusion technique, pyrazolones, thiosemicarbazides.