Open Chemistry Journal

2018, 5 : 18-31
Published online 2018 April 30. DOI: 10.2174/1874842201805010018
Publisher ID: CHEM-5-18

REVIEW ARTICLE
 Michael Addition of Imidazole to , -Unsaturated Carbonyl/Cyano Compound

Seetaram Mohapatra, * , Nilofar Baral , Nilima Priyadarsini Mishra , Pravati Panda and Sabita Nayak

* Address correspondence to this author at the Organic Synthesis Laboratory, Department of Chemistry, Ravenshaw University, Cuttack-753 003, Odisha, India, Tel: 7735675772; E-mail: seetaram.mohapatra@gmail.com

ABSTRACT

Introduction:

Aza-Michael addition is an important reaction for carbon-nitrogen bond formation in synthetic organic chemistry.

Expalantion:

Conjugate addition of imidazole to α,β-unsaturated carbonyl/cyano compounds provides significant numbers of the biologically and synthetically interesting products, such as β-amino acids and β-lactams, which have attracted great attention for their use as key intermediates of anticancer agents, antibiotics and other drugs.

Conclusion:

This review addresses most significant method for the synthesis of N-substituted imidazole derivatives following Michael addition reaction of imidazole to α,β-unsaturated carbonyl/cyano compounds using ionic liquid/base/acid/enzyme as catalysts from year 2007-2017.

Keywords:

Michael addition, Imidazole derivative, Methyl acrylate, Silica sulfuric acid, Heterocycles, Ionic liquids.