Open Chemistry Journal
2018, 5 : 51-63Published online 2018 June 29. DOI: 10.2174/1874842201805010051
Publisher ID: CHEM-5-51
RESEARCH ARTICLE
Novel (N) Macrocyclic Metal Complexes: Synthesis, Characterization, Spectral Studies and Anticancer Activity
2 Department of Pathology, University Hospital, Menoufia University, Shebin El- Kom,
* Address correspondence to this author at the Department of Chemistry, Faculty of Science, Menoufia University, Shebin El- Kom, Egypt; Tel: +20 111 7532777; Fax: +20 48 2235689.; E-mail: helboraey@yahoo.com
ABSTRACT
Introduction:
A new series of mononuclear Fe(II), Co(II), Ni(II), Cu(II) and Pd(II) complexes correspond to tetradentate macrocyclic nitrogen ligand i.e. naphthyl-3,4:10,11-dibenzo,7-methylene,8-methyl,6-phenyl-1,5,9,13-tetraazacyclohexadecane-5,8-diene-2,12-dione metal(II) complexes, have been synthesized by the template condensation reaction.
Methods:
The complexes have been characterized by elemental analysis, spectral (IR, UV–Vis, and ESR, molar conductivity, and magnetic as well as thermal analysis measurements.
Results:
On the basis of above studies, an octahedral geometry has been proposed for all complexes except Cu(II) nitrate complex that adopt square pyramidal geometry, and square planar geometry for Pd(II) chloride complex, respectively.
Conclusion:
The thermal behavior and the kinetic parameters of degradation were determined using Coats-Redfern and Horowitz-Metzger methods. Moreover, the in vitro antitumor activity of the some synthesized complexes against human breast and human hepatocarcinoma cell lines (MCF-7) and (HePG2), respectively has been studied.