Open Pharmaceutical Sciences Journal
2016, 3 : 196-202Published online 2016 August 19. DOI: 10.2174/1874844901603010196
Publisher ID: PHARMSCI-3-196
RESEARCH ARTICLE
Tissue-specific Effect of Coenzyme Q Supplementation on the Oxidative Post-translational Modifications in the Rat
* Address correspondence to this author at the Department of Chemistry, Panchmura Mahavidyalaya, Panchmura, Bankura, West Bengal 722 156, India; Tel: +091- 3243-268227/205222 (Office); Email: chandanjana@yahoo.com
ABSTRACT
Background:
Coenzyme Q (CoQ), a component of almost all cellular membranes, has been postulated to act as an antioxidant due to its capacity to recycle the oxidized alpha-tocopherol and scavenge peroxy radicals.
Objective:
The present study was performed to investigate the in vivo effects of a long-term supplementation of CoQ10 on oxidative protein modifications in some tissues as the plasma and the brain of the Sprague Dawley rat.
Method:
Male Sprague Dawley rats of 14 months age were supplemented with 150 mg/kg/d of CoQ10 and the effects on oxidative post-translational modifications analyzed after 13 weeks of supplementation.
Results:
Supplementation of CoQ10 for thirteen weeks in adult animals resulted in decreased protein carbonyls due to oxidative post-translational modifications in the plasma (approximately 21%) but an increase of the same in the brain tissue homogenate (approximately 21%) was observed. These alterations were statistically significant in the former while the increase in the latter was statistically not significant.
Conclusion:
The results suggest a tissue-specific effect of dietary supplementation of CoQ10 on oxidative post-translational modifications by carbonylation in the rats.