The Open Allergy Journal

2008, 1 : 19-25
Published online 2008 July 9. DOI: 10.2174/1874838400801010019
Publisher ID: TOALLJ-1-19

Effects of Seasonal Allergic Rhinitis on Driving Ability, Memory Functioning, Sustained Attention, and Quality of Life

Monique A.J. Mets , Edmund R. Volkerts , Erwin A. Dunnebier , Lieke M. de Senerpont Domis , Berend Olivier and Joris C. Verster
Utrecht Institute for Pharmaceutical Sciences, Department of Psychopharmacology, Utrecht University, PO BOX 80082, 3508 TB, Utrecht, the Netherlands.

ABSTRACT

Objective:

The objective of this study was to compare driving ability, memory, and psychomotor performance during grass pollen season with winter season in untreated patients with SAR.

Methods:

Patients with SAR were trained and tested during the grass pollen season (summer) and winter. An on-the-road driving test during normal traffic conditions was performed. Primary parameter is the Standard Deviation of Lateral Position (SDLP), i.e. the weaving of the car. In addition, a word learning test and continuous performance test were performed and quality of life was assessed. Patients were included if in winter the Total 5-Symptoms Score (T5SS) was < 3 and in summer the T5SS was > 3.

Results:

70 patients were recruited of which 22 started the study. Fifteen patients completed the study of which 11 met the inclusion criteria. These 11 patients had a mean T5SS of 6.8 in summer and 0.6 in winter. Patient reported a significantly reduced overall quality of life during grass pollen season (p<0.0001). No significant effects were found on the driving test, except a significant (but not relevant) decrease in mean speed during the grass pollen season (p<0.035). No significant effects were found on the word learning test and continuous performance test.

Conclusion:

Our data suggest that moderate SAR symptoms do not impair driving ability, memory functioning and continuous performance. However, given the small sample size future studies should confirm these findings.