The Open Antimicrobial Agents Journal
2010, 2 : 22-25Published online 2010 August 27. DOI: 10.2174/18765181010020200022
Publisher ID: TOANTIMJ-2-22
Role and Pathological Significance of Apoptosis Induced by Influenza Virus Infection
Department of Virology, Toyama Institute of Health, 17-1 Nakataikoyama, Imizu, Toyama 939-0363, Japan.
ABSTRACT
The role and pathological significance of apoptosis in an influenza virus-infected host has been hotly debated. Influenza virus-induced apoptosis was primarily thought to be a host defense mechanism to limit virus replication and eliminate viruses from the host; however, the virus has mechanisms not only to overcome but to utilize apoptosis for its efficient replication. Virus-induced apoptosis also plays a role in developing symptoms. Understanding the mechanisms underlying virus-induced apoptosis could enable us to conquer the threat of influenza.