The Open Catalysis Journal

2009, 2 : 33-39
Published online 2009 March 17. DOI: 10.2174/1876214X00902010033
Publisher ID: TOCATJ-2-33

One-Pot Synthesis of Substituted Coumarins Catalyzed by Silica Gel Supported Sulfuric Acid Under Solvent-Free Conditions

Reddy Benjaram M. , Thirupathi Boningari and Patil Meghshyam K.
Inorganic and Physical Chemistry Division, Indian Institute of Chemical Technology, Uppal Road, Hyderabad - 500 607, India.

ABSTRACT

A remarkable acceleration in the synthesis of substituted coumarins via Pechmann reaction catalyzed by silica gel supported sulfuric acid (H2SO4/silica gel) at 120°C in high yields under solvent-free reaction condition with short reaction times is described. This methodology offers momentous improvements over various options for the synthesis of coumarins with regard to yield of products, simplicity in operation and green aspects by avoiding toxic catalysts and solvents.

Keywords:

Pechmann reaction, phenols, reaction mechanism.