The Open Catalysis Journal

2009, 2 : 54-60
Published online 2009 April 14. DOI: 10.2174/1876214X00902010054
Publisher ID: TOCATJ-2-54

Stereoselective Aminomethylation of m-Cresol with Chiral Amine Mediated by 4 A0 Molecular Sieves Under Neat Conditions

Gholizadeh Mostafa
Department of Chemistry, Tarbiat Moallem University of Sabzevar, Sabzevar, Iran.

ABSTRACT

Aminomethylation at ortho position was performed with respect to hydroxyl group of m-cresol in the presence of carefully dried 4 0A molecular sieves under neat conditions. One pot, two components, Mannich reaction of m-cresol with imine at 600C under Solvent-free conditions affords the corresponding aminomethylated products in good yields, with moderate stereoselectivity.

Keywords:

Aminomethylation, mannich reaction, solvent-free conditions.