The Open Catalysis Journal
2010, 3 : 19-23Published online 2010 January 27. DOI: 10.2174/1876214X01003010019
Publisher ID: TOCATJ-3-19
Crystallization Optimizing of Cefradine
Application Technology Institute of China Petroleum Engineering Southwest Company, Qingyang Ditrict, Xiaoguanmiao, Street No. 25, Sichuan Chengdu City 610017, P.R. China.
ABSTRACT
Cefradine crystallization was studied under different conditions. The optimal conditions for crystallization were: dissolving temperature, 15°C; initial temperature in crystallization, 30°C; cooling temperature in crystallization, 0°C; and adding 1,2-propanediol as adjuvant agent with a volume ratio 0.2 of water solution. The yield of cefradine crystallization is about 92% under these conditions. The purity of cefradine crystals is over 98% under the same conditions. The average size of cefradine crystal is 500 μm. The content of cefalexin in crystal is reduced to only 0.36%.