The Open Catalysis Journal
2010, 3 : 83-86Published online 2010 October 29. DOI: 10.2174/1876214X01003010083
Publisher ID: TOCATJ-3-83
One Step Synthesis of 6-Amino-5-Cyano-4-Phenyl-2-Mercapto Pyrimidine Using Phosphorus Pentoxide
Department of Chemistry, Shivaji University, Kolhapur- 416 004, Maharashtra, India.
ABSTRACT
A simple and efficient approach towards one step synthesis of 6-amino-5-cyano-4-phenyl-2-mercapto pyrimidine and its hydroxyl derivatives have been developed by three component condensation of aromatic aldehydes, malononitrile and thiourea/urea in presence of phosphorus pentoxide (Scheme 1)..