The Open Catalysis Journal

2010, 3 : 87-91
Published online 2010 October 29. DOI: 10.2174/1876214X01003010087
Publisher ID: TOCATJ-3-87

The Novel Application of Chiral α-Ethylphenyl Amine Tartaric Acid Salts- Cyanosilylation of Prochiral Aldehydes

Luo Mei , Zhang Jia Hai , Yin Hao , Sun Jie and Hu Ke Liang
Hefei University of Technology, Department of Chemical Engineering, Hefei, 230009,China.

ABSTRACT

The α-ethylphenylamine tartaric acid salts 1a-1d were synthesized from R-(+)/S-(-)-α-ethylphenylamine by reacting with (2S,3S)-(+)/(2R,3R)-(-) dihydrobutanedioic acid. They were used as the catalysts in cyanosilylation of prochiral aldehydes to give the corresponding cyanohydrin trimethylsilyl ethers in moderate conversion at room temperature.

Keywords:

α-ethylphenylamine tartaric acid salts, R-(+)/S-(-)-α-ethylphenyl amine, (2S,3S)-(+)/(2R,3R)-(-) dihydrobutanedioic acid.