The Open Catalysis Journal

2011, 4 : 107-112
Published online 2011 September 12. DOI: 10.2174/1876214X01104010107
Publisher ID: TOCATJ-4-107

Catalytic Asymmetric Addition of Diethylzinc to Benzaldehyde Using α- Pinene-Derived Ligands

Ekaterina A. Koneva , Evgeniy V. Suslov , Dina V. Korchagina , Alexander M. Genaev , Konstantin P. Volcho and Nariman F. Salakhutdinov
Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 630090, Novosibirsk, Russia

ABSTRACT

The amines obtained from α-pinene and containing a phenol or pyridine fragment can be used as ligands in the asymmetric addition of diethylzinc to aromatic aldehydes; the enantiomeric excess (ee) was up to 80%. The enantioselectivity of the reaction is not very sensitive to the nature of substituents in the aromatic ring of aldehydes.