Diagnostic Methods for Contact Allergy to Metals

ABSTRACT

The epicutaneous patch testing is regarded as the best method of diagnosis for allergic contact dermatitis (ACD). Patch tests can be used to confirm a suspected allergic contact dermatitis and either to recommend avoidance of particular products or to recommend alternative products in a particular patient. It is based upon re-exposing the skin of the patient to suspected allergens under controlled conditions. Different test sites and test tapes can be used and different variables such as intrinsic penetration capacity, concentration, exposure time and vehicle can be changed to obtain an optimal bioavailability of the haptens. The ideal patch test should cause as few adverse reactions as possible, and be reproducible and specific. In this paper, the application fields, the advantages and the disadvantages of the patch tests are reviewed. Other diagnostic methods as the open test, the provocative test, the repeated open application test and the photopatch test are also discussed.

Keywords:

Contact dermatitis, patch test, open application test, provocative test, repeated application test, photopatch test..