The Open Chemical and Biomedical Methods Journal

2010, 3 : 108-114
Published online 2010 November 1. DOI: 10.2174/18750389010030100108
Publisher ID: TOCBMJ-3-108

Anodic Voltammetry of Ciprofloxacin and its Analytical Applications

Bengi Uslu , Burcin Bozal and Mehmet Emin Kuscu
Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, 06100, Tandogan, Ankara, Turkey.

ABSTRACT

The electrooxidative behavior and determination of ciprofloxacin at a glassy carbon electrode were investigated using cyclic, linear sweep, differential pulse and square wave voltammetric techniques. The dependence of the peak current and peak potentials on pH, concentration, nature of buffer, and scan rate were examined. The oxidation of ciprofloxacin gave a single and irreversible peak at glassy carbon electrode. The process was diffusion controlled. A linear response was obtained between 1.0 × 10-6 and 4.0 × 10-5 M in 0.1 M sulphuric acid for both techniques. The recovery studies were also achieved to check selectivity and accuracy of the methods. The proposed methods were applied for the determination of ciprofloxacin from pharmaceutical dosage forms without any time-consuming extraction, separation, adsorption steps. The repeatability, reproducibility, precision and accuracy of the proposed methods were investigated.

Keywords:

Ciprofloxacin, voltammetry, glassy carbon electrode, cyclodextrins, pharmaceutical dosage form.