The Open Chemical and Biomedical Methods Journal

2010, 3 : 27-36
Published online 2010 November 1. DOI: 10.2174/1875038901003010027
Publisher ID: TOCBMJ-3-27

Application of Electrochemical Methods for Analysis of Fluoroquinolones Antibacterial Agents and Fluoroquinolones-DNA Interactions

Abd-Elgawad Radi
Department of Chemistry, Faculty of Science (Dumyat), Mansoura University, 34517 Dumyat, Egypt.

ABSTRACT

This mini review describes the results regarding the voltammetric determination of micromolar, submicromolar and nanomolar concentrations of various fluoroquinolones antibacterial agents using both traditional hanging mercury drop electrode, carbon paste electrode, glassy carbon paste electrode and chemically modified electrodes. We concentrate on the interaction of quinolones with DNA in solution and at electrode surface in the context of the general development in the field.

Keywords:

Electrochemical methods, fluoroquinolones, DNA interaction, voltammetry.