The Open Chemical and Biomedical Methods Journal

2010, 3 : 86-89
Published online 2010 November 1. DOI: 10.2174/1875038901003010086
Publisher ID: TOCBMJ-3-86

Enantioselective Potentiometric Membrane Eectrodes Based on α-,β-and γ-Cyclodextrins as Chiral Selectors for the Assay of S-Deprenyl

Abd-Elgawad Radi and Shimaa Eissa
Laboratory of Electrochemistry Bucharest, National Institute of Research for Electrochemistry and Condensed Matter, 202 Splaiul Independentei Str., 060021, Bucharest, Romania.

ABSTRACT

Enantioselective, potentiometric membrane electrodes (EPMEs) based on α,β and γ-cyclodextrins (CDs) as chiral selectors were proposed for the assay of S-deprenyl. The response characteristics proved that the proposed EPMEs could be reliably used in the assay of S-deprenyl. The best slope is exhibited by the EPME based on β-cyclodextrin. The limits of detection are very low: 10-9 mol L-1 magnitude order for β-cyclodextrin based EPME, and 10-11 mol L-1 magnitude order for α, and γ-cyclodextrins based EPMEs. The surfaces of the electrodes are stable and easily renewable by polishing on alumina paper.

Keywords:

Enantioselectivity, potentiometric membrane electrode, enantioanalysis, cyclodextrins, S-deprenyl.