The Open Cancer Immunology Journal

2011, 4 : 1-9
Published online 2011 December 20. DOI: 10.2174/1876401001104010001
Publisher ID: TOCIJ-4-1

Correlations of Hormone Receptors (ER and PR), Her2/neu and p53 Expression in Breast Ductal Carcinoma Among Yemeni Women

Hussain Gadelkarim Ahmed , Mohammed Ali Al-Adhraei and Abdullah Kasim Al-Thobhani
University of Khartoum, 102, Faculty of Medical Laboratory Sciences, Khartoum, Sudan

ABSTRACT

Aims:

The purpose of this study was to determine if any relationship exists between Estrogen Receptor (ER), Progesterone Receptor (PR), Her2/neu, P53, and clinicopathological factors in female breast ductal carcinoma.

Materials and Methods:

One hundred and thirty seven (IDC=124, NIDC=13) ductal carcinomas were clinicopathologically and immunohistochemically analyzed and compared with 20 control cases of benign breast lesions in which assessment of Her- 2/neu, ER, PR, and P53 has been performed, prospectively. Chi-square analysis was then used to correlate the above observations.

Results:

The overall immunoexpression of ER, PR, Her2/neu and P53 were 43.8%, 27%, 30.6% and 48.9%, respectively, of the 137 ductal carcinomas. A significant Positive association between ER or PR expression with lymph node involvement was found ( p= 0.004, p= 0.022 respectively), while p53 was found to be negatively associated with lymph nodes involvement (p= 0.03, 0.02, respectively). P53 also associated negatively to lymph node status (P=0.03) and positively with borderline tumor grade (p= 0.03).

Conclusion:

There are high rates of positive expression of ER, PR, Her2/neu and P53 among Yamani women with breast ductal carcinoma.

Keywords:

ER, PR, Her2/neu and p53, Breast Carcinoma, Yemeni.