The Open Cancer Journal

2008, 2 : 12-14
Published online 2008 June 12. DOI: 10.2174/1874079000802010012
Publisher ID: TOCJ-2-12

The Use of AFP-Complexes to Induce Apoptosis in Cancer Cells

V. Pak
Constab Pharmaceutical Inc., MaRS Centre, Toronto, Canada.

ABSTRACT

An anticancer “magic bullet” should have both efficacy and specificity parts. We have used an effective Apoptosis Inducer to trigger the apoptosis. Alpha-fetoprotein was used to deliver Apoptosis Inducers specifically to cancer cells. The AFP-AI complex inhibited tumor growth in mice, enlarged mice life survival and has shown a 50% response in patients with metastatic colorectal cancer.

Keywords:

Cancer, apoptosis inducer, targeted delivery.