The Open Chemical Physics Journal

2011, 3 : 6-9
Published online 2011 March 11. DOI: 10.2174/1874412501103010006
Publisher ID: TOCPJ-3-6

Effect of Increasing N,N-Dimethylformamide Concentration on the Structure of Polysorbate 80 Micelles

Hideki Aizawa
Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotouge-machi Hirakata-City, Osaka, 573-0101, Japan.

ABSTRACT

The structures of micelles of the surfactant polysorbate 80 (Tween 80) in 0-50% aqueous N,N-dimethylformamide (DMF) solutions (pH 7.2, ionic strength 2.44 mM) were investigated by means of small-angle X-ray scattering. At all the tested DMF concentrations, core-shell cylinder micelles formed; that is, increasing the concentration of DMF did not result in changes in the shape of the micelles. These results indicate that increasing the concentration of polar solvents does not always result in changes in the shapes of surfactant micelles.

Keywords:

Micelle, small-angle X-ray scattering, micellar structure investigations, east-squares fit calculation, ternary system, core-shell cylinder micelles.