The Open Crystallography Journal

2010, 3 : 16-28
Published online 2010 March 25. DOI: 10.2174/1874846501003010016
Publisher ID: TOCRYJ-3-16

Thiosemicarbazone Metal Complexes: From Structure to Activity

Giorgio Pelosi
Dipartimento di Chimica Generale e Inorganica, Chimica Analitica, Chimica Fisica, viale GP Usberti 17a, 43124 Parma, Italy.

ABSTRACT

Thiosemicarbazones and their metal complexes are compounds that possess antitumor, antibacterial, antifungal and antiviral properties. For the foremost majority of cases the activity of the ligand is greatly enhanced by the presence of a metal ion. The most relevant papers recently published are reviewed with an attempt to find a relationship between common structural features and activity.

Keywords:

Thiosemicarbazones, bioactive metal complexes, biological activity, mechanisms of action, pharmacological applications.