The Open Cardiovascular and Thoracic Surgery Journal

2012, 5 : 38-42
Published online 2012 December 14. DOI: 10.2174/1876533501205010038
Publisher ID: TOCTSJ-5-38

Findings and Outcomes from a Retrospective Study of Non-Small Cell Lung Cancer Patients with Synchronous Solitary Brain Metastases. An Analysis of Six Cases

Keigo Sekihara , Kazuhito Funai , Kei Shimizu , Akikazu Kawase and Norihiko Shiiya
Department of Surgery, Hamamatsu University School of Medicine, 1-20-1, Handayama, Higashiku, Hamamatsu, Shizuoka, 431-3192, Japan.

ABSTRACT

Background:

The combined resection of primary non-small cell lung cancer (NSCLC) with synchronous solitary brain metastasis (SSBM) after treatment of SSBM is superior to other treatments for prolonging patients survival. This study reviewed the clinical records and follow-up data of six patients with NSCLC and SSBM to verify the validity of this treatment.

Methods:

Six NSCLC patients presenting with SSBM, who were treated at Hamamatsu University School of Medicine Hospital between January 2000 and December 2010, were retrospectively reviewed.

Results:

There was one long-term survival case. The mean follow-up time was 37 months. The 1- and 5-year overall survival rates for all patients were 50% and 33%, respectively. The median survival time (MST) for all patients was 40 weeks.

Conclusion:

Primary tumor resection in a NSCLC patients with SSBM is therefore considered to be an acceptable and effective surgical approach.

Keywords:

Aggressive trimodality treatment, Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI), Fiveyear tumor-free survival.