The Open Drug Discovery Journal

, 2 : 3-7
Published online . DOI: 10.2174/1877381801002010003
Publisher ID: TODDISJ-2-3

Protective Effect of Erythropoietin in Renal Ischemia-Reperfusion Injury

Nuray Yazihan and Guzin Ozelci Kavas
Ankara University, Faculty of Medicine, Pathophysiology department, Molecular Biology Research and Development Unit, Morfoloji Binasi, Sihhiye, Ankara 06100, Turkey.

ABSTRACT

Ischemia and/or reperfusion injury (IR) is one of the most common causes of acute renal failure. Erythropoietin (EPO), is main hematopoietic hormone that has recently been shown to exert important cytoprotective and anti-apoptotic effects in experimental I/R and toxicity models.

Recent studies suggest that administration of exogenous EPO prevents ischemia-induced kidney damage. In this review we focused on anti-apoptotic, anti-inflammatory and anti-oxidant action of EPO in renal ischemia-reperfusion models and its application in nephropathies. EPO seems to be a very promising agent for protecting cellular survival during both acute and chronic ischemic and toxic nephropathies.

Keywords:

Erythropoietin, kidney, ischemia reperfusion, oxidative stress, kidney, inflammation.