The Open Drug Delivery Journal

2008, 2 : 77-85
Published online 2008 October 22. DOI: 10.2174/1874126600802010077
Publisher ID: TODDJ-2-77

Hydrazone, Amide, Carbamate, Macromolecular and Other Prodrugs of Doxorubicin

Sevim Rollas and Güniz Küçükgüzel
Marmara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Haydarpa􀀈a, 34668, 􀀆stanbul, Turkey.

ABSTRACT

An important strategy for improving the antitumor selectivity and decreasing severe side effect of antitumor agents is to design carrier systems and prodrugs. Here, we review the most important prodrug models based on doxorubicin.

Keywords:

Doxorubicin, prodrug, hydrazone, amide, carbamate, macromolecular.