The Open Diabetes Journal

2018, 8 : 13-21
Published online 2018 July 31. DOI: 10.2174/1876524601808010013
Publisher ID: TODIAJ-8-13

CLINICAL TRIAL STUDY
Type 2 Diabetes Study, Introduction and Perspective

Da-Yong Lu1, * , Jin-Yu Che1 , Nagendra Sastry Yarla2 , Hong Zhu3 , Ting-Ren Lu1 , Bin Xu4 and Swathi Putta5

* Address correspondence to this author at the Shanghai University, Shanghai 200444, P. R. China, E-mail; ludayong@shu.edu.cn

ABSTRACT

Background:

The prevalence of Type 2 Diabetes Mellitus (T2DM) continues to rise globally. The T2DM prevalence is not only in developing countries, but also in developed countries now. Correspondingly, the therapeutics of T2DM calls for a change (higher efficiency) due to growing number of patients and increasing economic burdens globally. Entering into this millennium, both piecemeal pathways (idea driven) and exponential growth of human genomic study are developing quickly. Genetypic-phenotypic translation, modern diagnostics, pharmacology, drug developments, traditional Chinese medicine, personalized medicine and so on are promising disciplines for this change. The clinical anti-diabetic therapeutics, pathogenesis, drug development pipelines are especially highlighted.

Conclusion:

In summary, a general landscape and principle of T2DM is provided.

Keywords:

Anti-diabetic therapy, Insulin-derivatives, Natural chemotherapeutic drugs, Diabetes-induced complication, Traditional Chinese Medicine, Diabetic pathology, Herbal medicine.