The Open Drug Safety Journal

2011, 2 : 21-24
Published online 2011 January 26. DOI: 10.2174/1876818001102010021
Publisher ID: TODSJ-2-21

RESEARCH ARTICLE
 Assessment of Kidney Safety Parameters Among Hiv-Infected Patients Starting a Tenofovir-Containing Antiretroviral Therapy

Roberto Manfredi, * and Leonardo Calza

* Address correspondence to this author at the Infectious Diseases, University of Bologna, S. Orsola Hospital, Via Massarenti 11, I-40138 Bologna, Italy; Tel: +39 051 6363355; Fax: +39 051 343500; E-mail: roberto.manfredi@unibo.it

ABSTRACT

To better evaluate the renal safety profile of tenofovir, we performed a retrospective study of HIV-infected naïve patients starting a first antiretroviral therapy between July 2005 and July 2008, and followed-up for 24 months. On the whole, 324 patients were enrolled: 201 tenofovir-exposed patients were compared with 123 tenofovir-unexposed subjects. In both unadjusted and adjusted analysis, tenofovir-exposed subjects had a significantly greater decline in glomerular filtration rate (GFR), and a significantly higher incidence of proximal tubular dysfunction through 24 months. Reduced glomerular and tubular functions were significantly associated with older age, diabetes, hypertension, and concomitant therapy with a HIV protease inhibitor.

Keywords:

HIV, tenofovir, nephrotoxicity, glomerular filtration rate, tubulopathy.