The Open Environmental & Biological Monitoring Journal

2008, 1 : 43-47
Published online 2008 August 13. DOI: 10.2174/1875040000801010043
Publisher ID: TOEBMJ-1-43

Genetic Reconstruction of One Hereditary Nonpolyposis Colorectal Cancer History with Multiple Initiations of the Disease

Olga A. Vostrukhina , Tatyana A. Shtam , Alexey V. Gulyaev , Kazimir M. Pozharisski and Vladislav A. Lanzov
Division of Molecular and Radiation Biophysics, B.P. Konstantinov Petersburg Nuclear Physics Institute (PNPI), Russian Academy of Sciences, Gatchina/ St. Petersburg, 188300, Russia.

ABSTRACT

The scheme of accumulation of genetic alterations in a long-term case of hereditary nonpolyposis colorectal cancer (HNPCC) was reconstructed by the retrospective analysis of postoperative tissue materials. This unique case resulted from a primary lesion in MLH1 gene and revealed two genetic pathways of carcinogenesis in tumors separated by lifetime and localization.