Lack of Association between Anti-Ribosomal-P Antibody and Chemokines in Neuropsychiatric Syndromes of Systemic Lupus Erythematosus

ABSTRACT

Anti-ribosomal P protein antibody (anti-P) in cerebral spinal fluids (CSF) has been reported to associate with NPSLE and IgG anti-P in CSF was suggested to be a useful marker for the diagnosis of neuropsychiatric syndromes of systemic lupus erythematosus (NPSLE). There is growing evidence that chemokines, such as MCP-1/CCL2 and IP-10/CXCL10 are involved in the pathogenesis of NPSLE. To study the relationship between these markers in CSF from patients with NPSLE, we measured the levels of IgG anti-P, MCP-1/CCL2 and IP-10/CXCL10 in the same samples. We found no correlations between the titer of IgG anti-P antibody and IP-10/CXCL10 or MCP-1/CCL2, suggesting that IgG anti-P antibody and chemokine levels might discriminate the different subset of NPSLE symptoms.