The Open Hematology Journal

2011, 5 : 1-3
Published online 201101. DOI: 10.2174/1874276901105010001
Publisher ID: TOHJ-5-1

Features of Chronic Active Epstein-Barr virus Infection and Related Human Diseases

Motohiko Okano
Center for Infectious Diseases Control, Hokkaido Institute of Public Health, North 19 West 12, Kita-ku, Sapporo 060-0819, Japan.

ABSTRACT

A chronic undefined illness characterized by infectious mononucleosis (IM)-like symptoms and signs, possibly associated with Epstein-Barr virus (EBV) infection, designated as so-called chronic active EBV infection (CAEBV), is focused and discussed in this mini-review. Patients with CAEBV often develop T cell lymphoproliferative disorder (LPD)/lymphoma or NK cell LPD/lymphoma. Unique manifestations with generally poor prognosis of the disease prompt us to understand in particular the entity, diagnosis and treatment.

Keywords:

CAEBV, diagnosis, treatment..