The Open Hypertension Journal

2010, 3 : 1-13
Published online 2010 June 25. DOI: 10.2174/1876526201003010001
Publisher ID: TOHYPERJ-3-1

The Renin Angiotensin System and the Metabolic Syndrome

Chih-Hong Wang , Feng Li and Nobuyuki Takahashi
Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, 819 Brinkhous-Bullitt Building, Chapel Hill, NC 27599-7525, USA.

ABSTRACT

The renin angiotensin system (RAS) is important for fluid and blood pressure regulation. Recent studies suggest that an overactive RAS is involved in the metabolic syndrome. This article discusses recent advances on how genetic alteration of the RAS affects cardiovascular and metabolic phenotypes, with a special emphasis on the potential role of angiotensin-independent effects of renin.

Keywords:

(Pro) renin receptor, body fat, fecal fat.