The Open Immunology Journal

2008, 1 : 42-50
Published online 2008 November 18. DOI: 10.2174/1874226200801010042
Publisher ID: TOIJ-1-42

Different Evolution of Inhibitory and Activating Killer Immunoglobulin Receptors (KIR) in Worldwide Human Populations

Derek Middleton , Ashley Meenagh , Juan Ignacio Serrano-Vela , Juan Moscoso and Antonio Arnaiz-Villen
Departamento de Immunologia, Facultad de Medicina, Universidad Complutense de Madrid, Avenida Complutense s/n, 28040, Madrid, Spain.

ABSTRACT

HLA class I molecules are ligands for natural killer cells’ inhibitory (KIR DL) and activating (KIR DS) receptors. KIR DL receptors have a greater avidity for HLA class I molecules than KIR DS receptors. Thus, there is a possibility that HLA molecules drive KIR receptor selection.

We have used the percentage of individuals bearing the genes KIR 3DS1, 2DS1, 2DS2, 2DS3, 2DS4, 2DS5, 2DL1, 2DL2, 2DL3, 2DL5 and 3DL1 in relatively well defined populations to test whether there is a different way of relating worldwide populations between KIR DS and KIR DL molecules.

We have used ARLEQUIN, DISPAN and VISTA computer programs to construct dendrograms and correspondence analyses showing the genetic relationships among different human world populations. Analyses based on KIR DS or KIR haplotype B genes show that populations are related according to geography, like a good anthropological marker (i.e.: HLA or Y chromosome systems). The results based on KIR DL or KIR haplotype A genes do not show such a correlation. Results are discussed taking into account the linkage of both HLA and KIR systems to microbial diseases and the possible evolutionary shaping of both HLA and KIR receptors repertoire by pathogens.

Keywords:

Activating KIR, HLA, inhibitory KIR.