The Open Immunology Journal

2009, 2 : 127-134
Published online 2009 October 23. DOI: 10.2174/1874226200902010127
Publisher ID: TOIJ-2-127

Human γδ T Cells and Immune Regulation

Zheng W. Chen
Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine, USA.

ABSTRACT

Human γδ T cells appear to belong to non-classical T cells with both innate and adaptive immune features. Vγ2Vδ2 (also termed Vγ9Vδ2) T cell subset exists only in primates, and in humans that represents a major γδ T cell subpopulation in the blood. Vγ2Vδ2 T cells remain to be the only γδ T cell subpopulation that can recognize a welldefined foreign microbial phosphoantigen. This article reviews the recent progress in our understanding immune regulation of Vγ2Vδ2 T cells.

Keywords:

Immune regulation, CD4+CD25+Foxp3+ regulatory T cells, γδ T cells.