The Open Medical Devices Journal

2012, 4 : 66-72
Published online 2012 September 20. DOI: 10.2174/1875181401204010066
Publisher ID: TOMDJ-4-66

Short-term Efficacy of Narivent® in the Treatment of Nasal Congestion

Valerio Damiani , Angelo Camaioni , Claudio Viti , Giulia Schillani , Francesca Foltran , Antonella Silvia Scire , Giada Morpurgo and Dario Gregori
Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic and Vascular Sciences, Via Loredan, 18, 35121 Padova – Italy.

ABSTRACT

Rationale and aim:

Nasal congestion is a common symptom in rhinologic diseases such as rhinosinusitis, nasal polyposis and adenoid pathology. Although various pharmacotherapy options exist, no agent is universally efficacious. The aim of this study was to evaluate the efficacy of Narivent®, an osmotically acting medical device with antioedematous and anti-inflammatory effects, in a short-term (7days) treatment.

Methods:

A single-centre prospective study with a pre-post design was conducted with consecutive enrolment in an Italian Otolaryngology Department of 36 both genders patients with nasal congestion. Patients received 2 puffs of Narivent® into each nostril 2 times a day over the course of 1 week. The severity of symptoms was assessed subjectively as measured by a 0 to 10 visual analogue scale (VAS) and the presence/absence of symptoms and signs. Differences in subjective and objective severity measures before and after treatment were compared using Paired-Sample Wilcoxon Signed Rank Test.

Results:

A significant improvement after treatment (p<0.001) has been recorded for the main subjective symptoms and objective signs (overall symptom burden, nasal congestion, cephalea, turbinates hypertrophy, normal mucosa status).

Conclusion:

Study results confirm the efficacy of Narivent® in treating nasal congestion over a 1 week period.

Keywords:

nasal congestion, osmotically acting medical device, anti-oedematous activity.