The Open Medical Informatics Journal

2013, 7 : 18-23
Published online 2013 May 31. DOI: 10.2174/1874431120130427001
Publisher ID: TOMINFOJ-7-18

RESEARCH ARTICLE
 The Integrated Web Portal for Escalation with Overdose Control (EWOC)

Haibin Wang, * , Mourad Tighiouart , Shao-Chi Huang , Dror Berel , Galen Cook-Wiens , Catherine Bresee , Quanlin Li and André Rogatko
Biostatistics & Bioinformatics Research Center, Cedars-Sinai Medical Center, 116 N. Robertson Blvd, Los Angeles, CA 90048, USA

* Address correspondence to this author at the Biostatistics & Bioinformatics Research Center, Cedars-Sinai Medical Centre, 116 N. Robertson Blvd, Los Angeles, CA 90048, USA; Tel: 310-423-3315; Fax: 310-423-3315; E-mail: Haibin.wang@cshs.org

ABSTRACT

In this paper, we present the design and implementation of a novel web portal for the cancer phase I clinical trial design method Escalation with Overdose Control (EWOC). The web portal has two major components: a web-based dose finding calculator; and a standalone and downloadable dose finding software which can be installed on Windows operating systems. The web-based dose finding calculator uses industry standards and is a database-driven and distributed computing platform for designing and conducting dose finding in cancer phase I clinical trials utilizing EWOC methodology. The web portal is developed using open source software: PHP, JQuery, R and OpenBUGS. It supports any standard browsers with internet connection. The web portal can be accessed at: http://biostatistics.csmc.edu.

Keywords:

EWOC, Bayesian method, cancer phase I clinical trial, maximum tolerated dose, open source.