The Open Magnetic Resonance Journal

2009, 2 : 28-32
Published online 2009 February 12. DOI: 10.2174/1874769800902010028
Publisher ID: TOMRJ-2-28

Gadovosfeset Trisodium (Vasovist®) Enhanced MR Lymph Node Detection: Initial Observations

M.J. Lahaye , G.L. Beets , S.M.E. Engelen , M. Voth , T. Leiner , D.M.J. Lambregts and R.G.H. Beets-Tan
the University Hospital Maastricht, Department of Radiology, P. Debyelaan 25, 6229 HX Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands;

ABSTRACT

The aims of this study were to identify: (i) whether intravenous administrated Vasovist® is taken up by lymph nodes, (ii) the time of peak enhancement and (iii) the optimal MR sequence. Ten rectal cancer patients were evaluated with 4D THRIVE MRI at 0, 15, 30 and 60 minutes and with 3D T1W GRE at 0, 7, 17 and 32 minutes after intravenous Vasovist® administration. The signal intensity (SI) of individual lymph nodes, muscle, mesorectal fat and iliac artery on all images were measured with regions of interest and were evaluated. At histopathological examination 56 nodes were eligible for analysis. The results showed that (i) intravenously administrated Vasovist® shows enhancement in normal lymph nodes in rectal cancer patients, (ii) peak of enhancement is 15 (4D THRIVE) and 17 (3D T1W GRE) minutes and (iii) the 3D T1W GRE is the most optimal MR sequence.