The Open Neuroscience Journal

2007, 1 : 15-19
Published online 2007 December 7. DOI: 10.2174/1874082000701010015
Publisher ID: TONEURJ-1-15

Adenosine Kinase Expression Modulates Expression of Myelin Proteolipid Protein

Natalie Lai-man Wu and Detlev Boison
R.S. Dow Neurobiology Laboratories, Legacy Research, 1225 NE 2nd Ave, Portland, OR 97232, USA.

ABSTRACT

Adenosine is known to regulate myelination in vitro. Here we tested the hypothesis that adenosine, regulated by adenosine kinase (ADK), might regulate myelin-specific protein expression and myelination in vivo. We demonstrate that transgenic overexpression of ADK, which reduces adenosine in mouse brain, results in increased levels of myelin proteolipid protein.

Keywords:

Adenosine, transgenic mice, myelination.