Immune-Endocrine Alterations During Preeclampsia

ABSTRACT

Preeclampsia is a pregnancy-related disorder exclusive to human beings, and represents a public health problem worldwide whose etiology is still unknown. As diverse studies have reported, an understanding of the onset and course of this disorder depends on the knowledge about the interaction between the physiological systems of the organism, such as the immune, vascular and endocrine systems. Recently, in Mexican women with preeclampsia we genotyped the family of KIR genes and studied the phenotype of NK cells in peripheral blood and the decidua. Moreover, we are characterizing the proteins, such as HIF-1α and two of its more frequent genetic polymorphisms, as well as the pathways of their activation which participate in placental hypoxia The aim of the current study is to review the most recent contributions regarding the participation of the immune and vascular system during the development of preeclampsia, and the immunoendocrine alterations which result of them.

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