Amphetamine-Induced Conditioned Place Preference and Modeling Domains of Bipolar Disorder

ABSTRACT

paradigm As expected, amphetamine pairing resulted in the development of CPP, evidenced by an increase in the time spent in the paired compartment from pre-conditioning to post-conditioning sessions. Lithium had no effects on the expression of CPP or on locomotor activity. The results suggest that amphetamine-induced CPP lacks pharmacological validity and it is therefore not a good choice as a model for the reward-seeking domain of BPD. Additional tests should be explored as suitable modes for this important component of the disorder.