The Open Nitric Oxide Journal

2008, 1 : 1-4
Published online 2008 April 29. DOI: 10.2174/1875042700801010001
Publisher ID: TONOJ-1-1

Effect of Nitric Oxide on Platelet Progeneitor Growth, Posttranslational Modification of Protein, and Function

Thomas M. Chiang and Virginia Woo-Rasberry
Veteran Affairs Medical Center and Departments of Medicine and Molecular Sciences, University of Tennessee Health Science Center, Research Services (151), 1030 Jefferson Ave., Memphis, TN 38104, USA.

ABSTRACT

Nitric oxide (NO), formed through the action of nitric oxide synthase of platelets, which upon exposure to oxygen- free radical forming peroxynitrite, could be involved in posttranslational modification of platelet intra- and extracellular proteins. Platelet proteins modified through nitrotyrosylation and the S-nitrosylation can play very important roles in controlling platelet function.

Keywords:

Nitric oxide, platelet aggregation, platelet, nitrotyrosylation.