The Open Nitric Oxide Journal

2011, 3 : 8-15
Published online 2011 October 21. DOI: 10.2174/1875042701103010008
Publisher ID: TONOJ-3-8

The Red Blood Cell and Nitric Oxide: Derived, Stimulated, or Both?

Stephen T. Halpin , Kari B. Anderson , Paul A. Vogel and Dana M. Spence
Department of Chemistry, Michigan State University, East Lansing, MI 48824.

ABSTRACT

Following a brief introduction to properties of the red blood cell (RBC), this review will provide information pertaining to the role of the RBC as both a deliverer of nitric oxide (NO), and a stimulator of NO release via RBC generated ATP. In addition, an evaluation of the potential downstream effects of RBC-derived ATP, via its ability to stimulate NO in other cell types, will be provided. Collectively, it is now apparent that the RBC is a determinant in functions other than oxygen delivery alone.

Keywords:

nitric oxide, adenosine triphosphate, red blood cell, endothelial cells, platelets, vasodilation, hypoxia, transendothelium electrical resistance (TEER), microfluidic technology.