The Open Nutrition Journal

2008, 2 : 1-4
Published online 2008 March 19. DOI: 10.2174/1874288200802010001
Publisher ID: TONUTRJ-2-1

Contribution of Various Dietary Constituents to the Acid Base Status: Interest of Animal Models of Latent Metabolic Acidosis

AChristian Demigné , Houda Sabboh , Marie-Noëlle Horcajada and Véronique Coxam
UNH, INRA-Theix, 63122 St- Genes-Champanelle, France.

ABSTRACT

Animal models of metabolic acidosis are generally based on drastic treatments and are poorly suitable as models of latent metabolic acidosis (LMA). Specific rodent diets have been evaluated as LMA models, together with their responsiveness to dietary alkalinizing factors. Using this model, the possibility to obtain LMA states with moderate levels of protein intake was identified, pointing to the critical role of anions in the mineral moiety of the diet. The potential role of large intestine fermentations to acid-base control has also been examined with this model.

Keywords:

Latent metabolic acidosis, potassium, dietary organic anions.