The Open Obesity Journal

2014, 6 : 31-37
Published online 2014 August 6. DOI: 10.2174/1876823701406010031
Publisher ID: TOOBESJ-6-31

Serum Myostatin Levels are Elevated in Overweight Patients

Hui J. Zhu , Hong B. Yang , Xiang Q. Wang , Hui Pan , Dian X. Zhang , Nai S. Li , Lin J. Wang and Feng Y. Gong
Department of Endocrinology, Peking Union Medical College Hospital, 1# Shuaifuyuan, Wangfujing, Beijing, 100730, China.

ABSTRACT

Objective:

Myostatin has recently been proposed as an important factor that not only regulates skeletal muscle mass, but also body fat mass. The aim of our study is to explore serum myostatin levels in overweight patients and its association with metabolic-related characteristics.

Methods:

40 overweight patients and 40 normal weight controls were recruited, and serum myostatin were measured by ELISA methods and the relationships between myostatin and metabolic-related parameters were investigated.

Results:

Serum myostatin concentrations were significantly increased in overweight patients compared with normal weight controls (10.99±1.99 vs. 9.75±0.96 ng/ml, P=0.001) and positively correlated with body weight (r = 0.272, P=0.015), BMI (r = 0.263, P=0.018), waist circumference (r = 0.291, P=0.009), hip circumference (r = 0.336, P=0.002) and TNF-α (r = 0.611, P<0.001) in all subjects. Contrarily, serum adiponectin levels were negatively associated with body weight (r = -0.270, P=0.018), waist-to-hip ratio (WHR) (r = -0.253, P=0.027), TG (r = -0.235, P=0.040), ALT (r = -0.268, P=0.019), uric acid (UA) (r = -0.262, P=0.021) and positively correlated with HDL (r = 0.454, P<0.001).

Conclusion:

Serum myostatin levels in overweight patients are notably increased and positively correlated with BMI, body weight, waist and hip circumference, TNF-α, suggesting myostatin is a metabolic regulatory factor.

Keywords:

Adiponectin, myostatin, overweight.