The Open Organic Chemistry Journal

2008, 2 : 107-109
Published online 2008 November 28. DOI: 10.2174/1874095200801020107
Publisher ID: TOOCJ-2-107

A Convenient Reduction of α-Amino Acids to 1,2-Amino Alcohols With Retention of Optical Purity

Sun-Hee Hwang , Mark A. Blaskovich and Hwa-Ok Kim
Mimetica Pty. Limited, Institute for Molecular Bioscience, University of Queensland, 306 Carmody Road, St. Lucia, QLD 4072, Australia.

ABSTRACT

A convenient one-pot synthesis of 1,2-amino alcohols from 􀀁-amino acids with retention of optical purity by use of 1,1’-carbonyldiimidazole and sodium borohydride is described.

Keywords:

Amino acid, 1,2-amino alcohol, carbonyl diimidazole.