The Open Organic Chemistry Journal
2008, 2 : 41-45Published online 2008 June 9. DOI: 10.2174/1874095200801020041
Publisher ID: TOOCJ-2-41
Synthesis of Oligonucleotide Conjugates Carrying Viologen and Fluorescent Compounds
Institute for Research in Biomedicine
(IRB Barcelona), Institute for Advanced Chemistry of Catalonia
(IQAC), Spanish Research Council (CSIC), Networking Centre on Bioengineering,
Biomaterials and Nanomedicine (CIBER-BBN), Josep Samitier 1-
5, E-08028 Barcelona, Spain.
ABSTRACT
The preparation of oligonucleotide conjugates carrying viologen and fluorescein is described. Reaction of the appropriate carboxyl derivatives with oligonucleotides carrying aliphatic amino groups gave the desired compounds. A simple method for the introduction of the amino group at the 5’-end of the oligonucleotides is reported.