The Open Organic Chemistry Journal

2008, 2 : 65-67
Published online 2008 June 10. DOI: 10.2174/1874095200801020065
Publisher ID: TOOCJ-2-65

Suzuki–Miyaura Reaction of 4-Silyl-bromobenzenes with Phenylboronic Acid under Thermal and Microwave Conditions

István Greiner , Emília Hohmann , László Vida and György Keglevich
Gedeon Richter Plc., 1475 Budapest, Hungary.

ABSTRACT

The coupling reaction of phenylboronic acid with 4-silyl-bromobenzenes incorporating an ionic liquid support or its neutral analogue at 80 °C in DMF/H2O in the presence of Pd(PPh3)4 and Na2CO3 takes place much faster and more efficiently under microwave irradiation than under traditional heating. It is an attractive method to carry out the generally slow Suzuki–Miyaura reactions under microwave conditions.

Keywords:

Suzuki–miyaura reaction, 4-silyl substituted bromobenzenes, imidazolyl derivative.