The Open Organic Chemistry Journal

2011, 5 : 1-8
Published online 2011 June 3. DOI: 10.2174/1874095201105010001
Publisher ID: TOOCJ-5-1

Synthesis and Properties of Oligodeoxynucleotides Carrying 2-Aminopurine

Carme Fabrega , Santiago Grijalvo and Ramon Eritja
Institute for Research in Biomedicine (IRB Barcelona), Institute for Advanced Chemistry of Catalonia (IQAC), Spanish Research Council (CSIC), Networking Centre on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Baldiri Reixac 10, E-08028 Barcelona, Spain.

ABSTRACT

The use of benzoyl, isobutyryl and dimethylaminomethylidene groups for the protection of the exocyclic amino function of 2-aminopurine during oligonucleotide synthesis has been investigated. Best results in the synthesis were obtained with the monomers of 2-aminopurine protected with the isobutyryl group.