The Open Organic Chemistry Journal
2011, 5 : 1-8Published online 2011 June 3. DOI: 10.2174/1874095201105010001
Publisher ID: TOOCJ-5-1
Synthesis and Properties of Oligodeoxynucleotides Carrying 2-Aminopurine
Institute for Research in Biomedicine (IRB Barcelona), Institute for Advanced Chemistry of Catalonia (IQAC), Spanish Research Council (CSIC), Networking Centre on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Baldiri Reixac 10, E-08028 Barcelona, Spain.
ABSTRACT
The use of benzoyl, isobutyryl and dimethylaminomethylidene groups for the protection of the exocyclic amino function of 2-aminopurine during oligonucleotide synthesis has been investigated. Best results in the synthesis were obtained with the monomers of 2-aminopurine protected with the isobutyryl group.