The Open Organic Chemistry Journal

2012, 6 : 12-20
Published online 2012 April 16. DOI: 10.2174/1874095201206010012
Publisher ID: TOOCJ-6-12

A One-pot Multi-component Synthesis of Dihydropyrimidinone/Thione and Dihydropyridine Derivatives Biginelli and Hantzsch Condensations using -BuOK as a Catalyst Under Solvent-free Conditions

Abdelmadjid Debache , Louisa Chouguiat , Raouf Boulcina and Bertrand Carboni
Laboratoire des Produits Naturels d'Origine Vegetale et de Synthese Organique, Departement de Chimie, Faculte des Sciences Exactes, Universite Mentouri de Constantine, 25000 Constantine, Algerie.

ABSTRACT

The synthesis of various substituted Biginelli 3,4-dihydropyrimidinone/thione and Hantzsch 1,4-dihydropyridine derivatives has been achieved using a modified procedure in the presence of potassium ter-butoxide (t-BuOK) as a catalyst under solvent-free conditions, in good to excellent yields.

Keywords:

t-BuOK, Biginelli 3,4-dihydropyrimidinones/thiones, Hantzsch 1,4-dihydropyridines, one-pot condensation, sol-vent-free conditions.