The Open Organic Chemistry Journal

2013, 7 : 1-10
Published online 2013 April 30. DOI: 10.2174/1874095201307010001
Publisher ID: TOOCJ-7-1

Ecofriendly Synthesis in Aqueous Medium: An Expeditious Approach to New -Diethyl Amide Bearing Benzenemethanesulfonamides

Olayinka O. Ajani , Oluwole B. Familoni , Johnbull O. Echeme and Feipeng Wu
Department of Chemistry, Covenant University, Canaanland, Km 10 Idiroko Road, P.M.B. 1023, Ota, Ogun State, Nigeria.

ABSTRACT

An highly expeditious synthetic approach for the synthesis of benzenemethanesulfonamides (1a-k) and their new corresponding N,N-diethyl substituted amido moieties (2a-k) has been achieved in aqueous medium at room tem-perature. The reaction condition was thoroughly optimized thereby allowing significant rate enhancement and resulting into excellent yields. The chemical structures of the successful candidates were confirmed using elemental analytical and spectroscopic data such as IR, 1H NMR, 13C NMR and some selected mass spectral data.

Keywords:

sulfonamide, amino acids, spectroscopy.