The Open Organic Chemistry Journal

2015, 9 : 16-34
Published online 2015 February 20. DOI: 10.2174/1874095201509010016
Publisher ID: TOOCJ-9-16

Complex-Induced Proximity Effect in Lithiation: Unveiling Recent Potentials in Organic Synthesis of Biologically Relevant Heterocyclic Compounds

Olayinka O. Ajani , Michael O. Shomade , Abiola Edobor-Osoh , Christiana O. Ajanaku and Alice O. Ajani
Department of Chemistry, Covenant University, Canaanland, Km 10 Idiroko Road, P.M.B. 1023, Ota, Ogun State, Nigeria.

ABSTRACT

Reactions that convert carbon–hydrogen (C–H) bonds into carbon–carbon (C–C) or carbon–heteroatom (C–Y) bonds are attractive tools for organic chemists, potentially expediting the synthesis of target molecules via functional group interconversion. More explorative studies have shown Complex Induced Proximity Effect (CIPE) to be a solutionprovider for the synthesis of bioactive compounds. This might act as excellent pathfinders to new drugs for combating microorganisms’ resistance challenges to old existing drug. So, a constant review into CIPE and lithiation chemistry is crucial because they offer excellent pathways to new heterocyclic compounds which are essential agents in drug design and discovery.

Keywords:

Aziridine, bioactive heterocycles, cipe mechanism, enantioselective, lithiation, stereoselectivity.